11/30/2023 0 Comments Define fragment in grammar(Dorothy Sayers, Murder Must Advertise, 1933) Vote for Punkin and Protect your Profits. Snagsbury's Soups are Best for the Troops. Children love Laxamalt. Prepare to meet thy God. Eat more Oats. Take Care of your Complexion. Pressing downward: their power in their weight." The new Africans, pot-bellied, heavy-jowled men on their stools of office: Cetshwayo, Dingane in white skins. Plotting against each other too: slow peasant plots that take decades to mature. Heavy eyelids, piggish eyes, shrewd with the shrewdness of generations of peasants. Sitting in a circle, debating ponderously, issuing degrees like hammer blows: death, death, death. Eating and talking, munching lives, belching. "What absorbs them is power and the stupor of power. (Alfred Jingle in Charles Dickens, The Pickwick Papers, 1837) "'Ah! fine place,' said the stranger, 'glorious pile - frowning walls - tottering arches - dark nooks - crumbling staircases - Old cathedral too - earthy smell - pilgrims' feet worn away the old steps - little Saxon doors - confessionals like money-takers' boxes at theatres - queer customers those monks - Popes, and Lord Treasurers, and all sorts of old fellows, with great red faces, and broken noses, turning up every day - buff jerkins too - matchlocks - Sarcophagus - fine place - old legends too - strange stories: capital' and the stranger continued to soliloquize until they reached the Bull Inn, in the High Street, where the coach stopped." (Mark Hellinger, "New Year's Eve on Broadway." Moon Over Broadway, 1931) Bad booze putting hics into hicks and bills into tills.
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11/30/2023 0 Comments Swift note collateralSwift was studying for his master's degree when political troubles in Ireland surrounding the Glorious Revolution forced him to leave for England in 1688, where his mother helped him get a position as secretary and personal assistant of Sir William Temple at Moor Park, Farnham. in 1686 "by special grace." Adult life Maturity Swift was an above-average student but not exceptional, and received his B.A. The basic skill taught the students was debate, and they were expected to be able to argue both sides of any argument or topic. The lectures were dominated by Aristotelian logic and philosophy. The four-year course followed a curriculum largely set in the Middle Ages for the priesthood. He attended Trinity College Dublin in 1682, financed by Godwin's son Willoughby. The artist had married into the Swift family Jonathan Swift in 1682, by Thomas Pooley. He had not, and thus began his schooling in a lower form. He arrived there at the age of six, where he was expected to have already learned the basic declensions in Latin. Swift's benefactor and uncle Godwin Swift took primary responsibility for the young man, sending him with one of his cousins to Kilkenny College (also attended by philosopher George Berkeley). His uncle Thomas Swift married a daughter of poet and playwright Sir William Davenant, a godson of William Shakespeare. His great-great-grandmother Margaret (Godwin) Swift was the sister of Francis Godwin, author of The Man in the Moone which influenced parts of Swift's Gulliver's Travels. The same grandmother's aunt Katherine (Throckmorton) Dryden was a first cousin of Elizabeth, wife of Sir Walter Raleigh. His grandmother Elizabeth (Dryden) Swift was the niece of Sir Erasmus Dryden, grandfather of poet John Dryden. Swift's family had several interesting literary connections. The house in which Swift was born 1865 illustration His nurse returned him to his mother, still in Ireland, when he was three. He said that there he learned to read the Bible. Īt the age of one, child Jonathan was taken by his wet nurse to her hometown of Whitehaven, Cumberland, England. His mother returned to England after his birth, leaving him in the care of his uncle Godwin Swift (1628–1695), a close friend and confidant of Sir John Temple, whose son later employed Swift as his secretary. He died of syphilis, which he said he got from dirty sheets when out of town. He died in Dublin about seven months before his namesake was born. Swift's father joined his elder brother, Godwin, in the practice of law in Ireland. Some time thereafter, Ericke and his family, including his young daughter Abigail, fled to Ireland. In 1634 the vicar was convicted of Puritan practices. His maternal grandfather, James Ericke, was the vicar of Thornton in Leicestershire. His father was a native of Goodrich, Herefordshire, but he accompanied his brothers to Ireland to seek their fortunes in law after their Royalist father's estate was brought to ruin during the English Civil War. He was the second child and only son of Jonathan Swift (1640–1667) and his wife Abigail Erick (or Herrick) of Frisby on the Wreake. Jonathan Swift was born on 30 November 1667 in Dublin in the Kingdom of Ireland. His deadpan, ironic writing style, particularly in A Modest Proposal, has led to such satire being subsequently termed "Swiftian". He was a master of two styles of satire, the Horatian and Juvenalian styles. He originally published all of his works under pseudonyms-such as Lemuel Gulliver, Isaac Bickerstaff, M. He is regarded by the Encyclopædia Britannica as the foremost prose satirist in the English language. Swift is remembered for works such as A Tale of a Tub (1704), An Argument Against Abolishing Christianity (1712), Gulliver's Travels (1726), and A Modest Proposal (1729). Jonathan Swift (30 November 1667 – 19 October 1745) was an Anglo-Irish satirist, author, essayist, political pamphleteer (first for the Whigs, then for the Tories), poet, and Anglican cleric who became Dean of St Patrick's Cathedral, Dublin, hence his common sobriquet, "Dean Swift". 11/30/2023 0 Comments Australia lockdown escapeMelbourne saw the largest march, with demonstrators clashing with police.
11/29/2023 0 Comments Collagen catabolismIn the present study, we investigated the effect of LRG1 on extracellular matrix (ECM) integrity in fibroblasts, as well as on skin aging. Leucine-rich alpha-2-glycoprotein 1 (LRG1) mediates skin repair and fibrosis by stimulating the transforming growth factor-beta (TGF-ß) signaling pathway. , Transforming Growth Factor beta/metabolism We inferred that the decline in SPARC expression in aged skin contributes to process of skin aging by negatively affecting ECM integrity in fibroblasts. These results indicated that SPARC enhanced ECM integrity by activating the TGF-ß signaling pathway in fibroblasts. RT-qPCR confirmed that a subset of differentially expressed genes is induced by SPARC. Transcriptome analysis revealed that SPARC modulated expression of genes involved in ECM synthesis and regulation in fibroblasts. An inhibitor of transforming growth factor-beta (TGF-ß) receptor type 1 reversed the SPARC-induced increase in type I collagen and decrease in MMP-1, and decreased SPARC-induced R-SMAD phosphorylation. In addition, SPARC also induced receptor-regulated SMAD (R-SMAD) phosphorylation. In a three-dimensional culture of foreskin fibroblasts mimicking the dermis, SPARC significantly increased the synthesis of type I collagen and decreased its degradation. Incubating foreskin fibroblasts with recombinant human SPARC led to increased type I collagen production and decreased matrix metalloproteinase-1 (MMP-1) secretion at the protein and mRNA levels. We found decreased SPARC expression in aged skin. The matricellular secreted protein acidic and rich in cysteine (SPARC also known as osteonectin), is involved in the regulation of extracellular matrix (ECM) synthesis, cell-ECM interactions, and bone mineralization. These data demonstrate that the impact of OI on myocardial mechanics includes cardiomyocyte adaptations beyond known direct effects on the extracellular matrix. The data reveal the hypercontractility of OI CMs with rapid rundown when exposed to acute stiffness challenges, extending our understanding of OI. This represents the first assessment of cardiomyocyte mechanics in OI. Together these data confirm multiple CM-level adaptations to low stiffness that extend our understanding of OI in the heart and how CMs respond to extracellular stiffness.NEW & NOTEWORTHY In a rare donation of a heart from an individual with osteogenesis imperfecta (OI), we explored cardiomyocyte (CM) adaptations to low stiffness. Levels of detyrosinated α-tubulin, known to be responsive to extracellular stiffness, were reduced in OI CMs. In response to 48 h of culture on surfaces with physiological (10 kPa) and pathological (50 kPa) stiffness, OI CMs demonstrated a greater reduction in contractility than nonfailing CMs, suggesting that OI CMs may have an impaired stress response. Interestingly, OI CMs were hypercontractile relative to nonfailing controls after 24 h of culture. However, CMs retained normal viscoelastic properties as revealed by nanoindentation. Trabecular stretch confirmed low stiffness on the tissue level. Proteomics and histology confirmed strikingly low expression of collagen 1. Here, we explore the tissue-level and CM-level properties of a heart from a deceased organ donor with OI type I. Although reduced collagen in OI hearts has been associated with reduced myocardial stiffness and left ventricular remodeling, its impact on cardiomyocyte (CM) function has not been studied. Osteogenesis imperfecta (OI) is an extracellular matrix disorder characterized by defects in collagen-1 transport or synthesis, resulting in bone abnormalities. And there’s plenty more where that came from. LA, Earl Manigault, jazz, fighting Bruce Lee, Kareem’s conservatism, dancing with Thelonious Monk, and why no one today can shoot a skyhook. 6) Tyler and Kareem talk segregation, Islam, Harlem vs. Email us: Learn more about Conversations with Tyler and other Mercatus Center podcasts here. Kareem Abdul-Jabbar on Jazz, Fighting Bruce Lee, Growing Up in Harlem, and Basketball (Ep. Read a full transcript enhanced with helpful links, or watch the full video.Rick Rubin has been behind some of the most iconic and successful albums in music history, and his unique approach to production and artist development has made him one of the most respected figures in the industry. He joined Tyler to discuss how to listen (to music and people), which artistic movement has influenced him most, what Sherlock Holmes taught him about creativity, how.Peter joined Tyler to discuss whether utilitarianism is only tractable at the margin, how Peter thinks about the meat-eater problem, why he might side with aliens over humans, at what margins he would police nature, the utilitarian approach to secularism and abortion, what he’s learned producing the Journal of Controversial Ideas, what he’d change about the current Effective Altruism movement, where Derek Parfit went wrong, to what extent we should respect the wishes of the dead, why professional philosophy is so boring, his advice on how to enjoy our lives, what he’ll be doing after retiring from teaching, and more. 10 Best episodes of Conversations with Tyler Podcast. The wide range of guests, spanning different disciplines and interests, provides a richness that is sure to satisfy your intellectual curiosity. Peter Singer is one of the world’s most influential living philosophers, whose ideas have motivated millions of people to change how they eat, how they give, and how they interact with each other and the natural world. Tyler Cowen engages today’s deepest thinkers in wide-ranging explorations of their work, the world, and everything in between. Just like Conversations with Tyler, this podcast presents engaging and thought-provoking discussions that leave listeners inspired to think and learn. 11/29/2023 0 Comments Update core ftp leIf these are a must then you'll have to opt for Core FTP Pro (licences start at $34.95), but otherwise Core FTP LE 2.1 should provide all the file transfer protocol you need. The program won't display thumbnails of your remote directories, and there's no email notification of a successful transfer. So where's the catch? There's no scheduler, encryption or integrated ZIP support. And although the company would like you to buy the program's big brother, Core FTP Pro, the Lite version doesn't nag you, display ads, or employ any other annoying tactics to try and change your minds. There's an Explorer-type window for browsing your local system, another to navigate the remote server, a Site Manager to store your logon details and a status window to keep you in touch with what's going on - it's all very straightforward.Įxplore the menus, though, and you'll find there's plenty of power here, with SFTP/SSH, SSL/TLS, and HTTP/HTTPS support, FTP/HTTP/SOCKS proxy, bandwidth control, and retry, resume and auto-reconnect options, amongst many other useful features. The program has an intuitive interface that means you'll feel immediately at home. FTPShell Client - It is a windows file transfer program that enables users to reliably transfer files, upload to websites, and download updates from the internet.Core FTP LE is an easy-to-use FTP client, that, despite the "Lite Edition" tag, is packed with powerful features.Direct FTP - The Only Drag and Drop FTP Client that Edits HTML, Previews Images and More!. The most frequent installer filenames for the software are: coreftp.exe, boomftp.exe, Core FTP Lite.exe, FTP.EXE and ShlFtp.exe etc. This download was checked by our antivirus and was rated as clean. The program belongs to Internet & Network Tools. AdArmor - Block popups, advertisers, annoying messages and many other unwanted things when you surf the Internet! Core FTP 2.2 can be downloaded from our software library for free.And it also can stop the windows that popup when you close your IE. The User Interface is quite outdated and it has to be updated with the. Super Popup Blocker - It can stop all pop-up windows even if the windows are very clever. Core FTP LE - free Windows software that includes the client FTP features you.Both versions of Core FTP offer you everything you need to connect and. Core FTP Pro is the low-cost supported version. There are two versions available: Core FTP LE is the free version. Development began in 2002, and it is maintained by. File Lock - Download File Lock to Protect or hide any of your files, folders and drives! Core FTP is an great commercial FTP client for Microsoft Windows.Privacy Sweeper - Download Privacy Sweeper to protect your privacy by sweeping private information stored in your computer.My Privacy - probe the confidential information and eliminate traces to identify your system's privacy level.
11/29/2023 0 Comments Cinemagraph pro dropboxCinemagraph ProĬinemagraph Pro is a professional tool specifically designed for the creation of living photos. It is also localized in 10 different languages. SkyGuide is accessible to star-gazer of all levels, with every feature available without a Wi-Fi, data or GPS signal. Users can use filters to investigate the sky with invisible wavelengths of light and view hidden wonders like supernova remnants, black holes, and the cosmic microwave background. Hold your device to the sky to automatically find stars, constellations, planets, satellites and more. SkyGuide brings a creative and detailed approach to exploring the world above us. Apple describes the recipients of this years awards as apps that “raise the bars in design, technology and innovation.” Winners received one of every Apple device and the Apple Design Award trophy. This special award recognizes apps that combine design and technology in creative, compelling and powerful ways. Although iOS8 doesn’t come out until the fall, the beta test will encourage developers to create software and products that will work with HomeKit.Īpple also announced the winners of its annual Apple Design Awards. The HomeKit platform will allow users to control locks, lights, cameras, doors, thermostats, plugs and switches via one iOS8 app, without the need for multiple apps to control each device or function. That means users will be able to try early versions of apps before their official release, and developers will be able to get ahead of bugs sooner in the process. Apple is also allowing developers to offer their apps as public beta download through TestFlight. The company also unveiled iOS8, the new version of iOS, which will come to iPhones and iPads in the fall.Īmong the plenty of software updates introduced at WWDC 2014, the most notable are, Revamped App StoreĪpple introduced a number of improvements to the iOS App Store that developers have asked for. At its Worldwide Developers Conference, Apple showed off new operating systems for iPhone,iPad and Mac, along with initiatives that touch the health-tracking and smart home markets, a slew of features like third-party keyboards,and even a new programming language.Īpple finally took the wraps off its desktop operating system Mac OS X 10.10 at WWDC 2014, now officially known as Yosemite. |
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